Integrated into Order Entry, ActX checks medications against the patient's genetics every time physicians write a prescription, alerting physicians if there is an issue with adverse effects, efficacy or dosing. ActX covers most U.S. prescription drugs for which there is evidence of a genomic effect. For example, a significant percentage of the U.S. population likely gets no pain relief from codeine based on their genetics, and ActX can alert clinicians to these patients.
ActX also alerts physicians for actionable patient genomic risks, such as hereditary cancers and cardiovascular risks. For example, patients with the genetic condition Lynch syndrome can have up to a 70% lifetime risk of colorectal cancer. These patients need to begin colorectal cancer screening at age 20 or 30. Inside the Genomic tab, the ActX Patient Genomic Profile displays a summary of all affected medications, risks, risk factors, and the patient's carrier status.
With real-time, integrated clinical decision support, ActX is designed for the workflow of busy clinicians that do not have to be experts in medical genetics. Decision support comes from the evidence-based KnowledgeBase, which includes references, and is updated when there is sufficient clinical validity and evidence. For institutions, ActX makes it easy to modify any clinical content or variant curation and allows for selective overrides of drug-genome interactions, actionable risks, and triggering variants. If no override is applied, the ActX KnowledgeBase original content is defaulted to.
Patient genetic data can be imported from any clinically valid source. ActX also offers optional, saliva-based micro-array testing for 600,000 variants that can be ordered through Order Entry. Testing through ActX covers pharmacogenomics, actionable risks, and carrier status.
After genomic data is on file for a patient, our GenoACT℠ Service is automatically activated. The authorizing physician will be alerted through the normal result inbox when the patient's data is first available, and when any serious genomic based medical risk is found (data is frequently reanalyzed). Every time a prescription is written, it will be checked for drug-genome interactions and will alert the prescriber if an actionable drug-genome alert is found. An up-to-date patient Genomic Profile can be checked under the Genomic tab at any time.
*ActX is not endorsed, certified or sponsored by Epic, or affiliated with its products and services.
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